3-Chloro-4-hydroxybenzoic acid → 4-Benzyloxy-3-chloroaniline

반응식

[Cl:1]C1C=C(C=CC=1O)C(O)=O.[CH2:12]([O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[C:22](Cl)[CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][C:21]=1[Cl:1])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

반응물 2

HCID 198603-Chloro-4-hydroxybenzoic acid

HCID 218271224-(Benzyloxy)-2-chloroaniline

생성물 1

HCID 12682854-Benzyloxy-3-chloroaniline

실험 절차

The 4-benzyloxy-3-chloroaniline was prepared from 3-chloro-4hydroxybenzoic acid using the same procedure described for the preparation of 4-benzyloxy-2-chloroaniline (Scheme 3). 1H NMR (300 MHz, CDCl3) δ:7.35 (m, 5 H), 6.77 (d, J=8.9 Hz, 1 H), 6.72 (d, J=2.1 Hz, 1 H), 6.49 (dd, J=8.9, 2.1 Hz, 1 H), 5.2 (s, 2 H), 3.55 (br s, 2 H).

출처 및 근거

ORD 기록: ord-41547263e17d4d2ca7323c82c294d108
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05622967

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