Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 1-(m-Methoxyphenyl)-2-cyclohexene-1-propionitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 1-(m-Methoxyphenyl)-2-cyclohexene-1-acetonitrile | HCID 12838393 | — |
| 반응물 | 1-(m-Methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile | HCID 20460002 | — |
| 반응물 | 1-(m-Methoxyphenyl)-2-oxo-cyclohexane-propionitrile | HCID 20460008 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 1-(m-Methoxyphenyl)-2-cyclohexene-1-propionitrile | HCID 20460009 | — |
반응 단계
By reducing 1-(m-methoxyphenyl)-2-oxo-cyclohexane-propionitrile with sodium borohydride and subsequently dehydrating the resulting 1-(m-methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile with phosphorus oxychloride in pyridine in analogy to the preparation of 1-(m-methoxyphenyl)-2-cyclohexene-1-acetonitrile described in Example 1, there is obtained 1-(m-methoxyphenyl)-2-cyclohexene-1-propionitrile in the form of a pale yellowish oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04448991 |
| 출처 데이터셋 | uspto-grants-1984_05 |
| ORD ID | ord-626384479d06429d913706bb25191e53 |
| 출처 메모 | uspto-grants-1984_05 |