1-Methyl-3-phenylpropylamine → HCID 15572772, 화합물

HRID 544365

반응식

HRID 544365 반응식
[CH3:1][CH:2]([NH2:11])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[C:12]([C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[O:16][CH2:17][CH:18]1[O:20][CH2:19]1)#[N:13]>C(O)C>[C:12]([C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[O:16][CH2:17][CH:18]([OH:20])[CH2:19][NH:11][CH:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)#[N:13]

참가 물질

4

반응물 2

HCID 311601-Methyl-3-phenylpropylamineHCID 126196712-(Oxiran-2-ylmethoxy)benzonitrile

생성물 1

HCID 15572772HCID 15572772, 화합물수율 613.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In this example, 1.5 g of 1-methyl-3-phenylpropylamine and 1.8 g of 1-(2-cyanophenoxy)-2,3-epoxypropane are refluxed for 1.5 hours in 50 ml of99.5% ethanol. After completion of the reaction, the reaction solution is concentrated under reduced pressure. The residue is then charged on a column packed with silica gel and the elution is carried out with methanol. The main fraction of the eluate is concentrated under reduced pressure. Then, the residue is recrystallized from 200 ml of n-hexane to obtain 20 g of 1-(2-cyanophenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol as crystals. (Yield: 62%)

후처리

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution is concentrated under reduced pressure
  3. additionThe residue is then charged on a column
  4. washthe elution
  5. concentrationThe main fraction of the eluate is concentrated under reduced pressure
  6. customThen, the residue is recrystallized from 200 ml of n-hexane

출처 및 근거

ORD 기록
ord-7981143449d14842a9c2a0b52c177a09
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450115

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