Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 22-iododocosanoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Tosylchloramide | HCID 31388 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 21-Docosenoic acid | HCID 4434004 | — |
| 반응물 | CID 15879360 | HCID 15879360 | — |
| 생성물 | 22-iododocosanoic Acid | HCID 9876391 | — |
반응 단계
21-Docosenoic acid (55mg. 0.16 mmol) was hydroborated with dicyclohexylborane (0.32 mmol) at 0° C. The organoborane was iodinated with a mixture of sodium aceate (0.32 mmol), sodium iodide (0.16 mmol), and chloramine-T (0.32 mmol). The product was isolated by a column chromotography on silica gel (10% ethyl acetate:hexane):yield 68 mg (91%); mp 71°-2° C.; m/e 466.5 (calcd 466.5); NMR (CDCl3), 1.2 δ (s, 36H, alkane), 2.1 (m, 4H, --CH2 --CO2H and --CH2CH2I), 3.0 (t, 2H, --CH2I, 11.9 (s, 1H, --CO2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04450149 |
| 출처 데이터셋 | uspto-grants-1984_05 |
| ORD ID | ord-e824cab9876c419ea204dc475ae04813 |
| 출처 메모 | uspto-grants-1984_05 |