Ethyl 2-phenoxy-5-thiazolecarboxylate → (2-Phenoxy-5-thiazolyl)-methanol
반응식
[O:1]([C:8]1[S:9][C:10]([C:13](OCC)=[O:14])=[CH:11][N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[O:1]([C:8]1[S:9][C:10]([CH2:13][OH:14])=[CH:11][N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
A solution of 12 g of the product of Step A in 100 ml of tetrahydrofuran was added dropwise to a mixture of 2.8 g of lithium aluminum hydride in 200 ml of tetrahydrofuran and the mixture was refluxed for 24 hours. Excess hydride was destroyed by addition of ethyl acetate and aqueous 2N hydrochloric acid was added thereto. The mixture was filtered and the aqueous phase was extracted with ether. The combined organic phases were evaporated to dryness to obtain 5.2 g of (2-phenoxy-5-thiazolyl)-methanol.
후처리
- temperaturethe mixture was refluxed for 24 hours
- customExcess hydride was destroyed by addition of ethyl acetate and aqueous 2N hydrochloric acid
- additionwas added
- filtrationThe mixture was filtered
- extractionthe aqueous phase was extracted with ether
- customThe combined organic phases were evaporated to dryness
출처 및 근거
- ORD 기록
- ord-0514113b99734879827ca93f68766321
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04450169
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