Potassium Carbonate → [5-phenoxy-(1,2,4)-thiadiazol-3-yl]-methyl (1R,3R) 2,2-dimethyl-3-(2,2-dibromoethenyl)-cyclopropane-1-carboxylate

A mixture of 3.3 g of (1R,3R) 2,2-dimethyl-3-(2,2-dibromoethenyl)-cyclopropane-1-carboxylic acid, 2.2 g of the product of Step A, 1.5 g of potassium carbonate, 100 mg of 1,4,7,10,13,16-hexaoxacyclooctadecane and 50 ml of methyl ethyl ketone wasrefluxed for 24 hours and was evaporated to dryness under reduced pressure.The residue was added to water and the aqueous mixture was extracted with ethyl acetate. The organic phase was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution withbenzene yielded 2.84 g of [5-phenoxy-(1,2,4)-thiadiazol-3-yl]-methyl (1R,3R) 2,2-dimethyl-3-(2,2-dibromoethenyl)-cyclopropane-1-carboxylate.

1. customwas evaporated to dryness under reduced pressure
2. additionThe residue was added to water
3. extractionthe aqueous mixture was extracted with ethyl acetate
4. customThe organic phase was evaporated to dryness under reduced pressure
5. customthe residue was chromatographed over silica gel
6. washElution withbenzene

ORD 기록

ord-041ae84039fd4bfe8db51abe152182b9

출처 데이터셋

uspto-grants-1984_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04450169