Phenethyl Isothiocyanate → 1-Piperazinecarbothioamide, N-(2-phenylethyl)-4-pyrazinyl-

HRID 544483

반응식

HRID 544483 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH2:13]([N:21]=[C:22]=[S:23])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CCOCC>[CH2:13]([NH:21][C:22]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:23])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 16741Phenethyl IsothiocyanateHCID 27346391-Piperazinylpyrazine

생성물 1

HCID 34820101-Piperazinecarbothioamide, N-(2-phenylethyl)-4-pyrazinyl-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 30 ml. of anhydrous ether is added dropwise a solution of 4.89 g. of phenethyl isothiocyanate in 30 ml. of anhydrous ether over 10 minutes. An additional30 ml. of anhydrous ether is required to maintain stirring over 30 minutes.The resulting solid is collected, dissolved in 100 ml. of benzene and 25 ml. of ethanol and cooled. The resulting solid is collected, giving 5.68 g. of the desired product as a white solid, m.p. 162°-163° C.

후처리

  1. temperatureto maintain
  2. customThe resulting solid is collected
  3. dissolutiondissolved in 100 ml
  4. temperatureof ethanol and cooled
  5. customThe resulting solid is collected
  6. customgiving 5.68 g

출처 및 근거

ORD 기록
ord-442cb34a276749408afea4694e9fb418
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450272

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