1,3-Dichloro-2-isothiocyanatobenzene → N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carbothioamide

HRID 544484노트

반응식

HRID 544484 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[N:21]=[C:22]=[S:23]>CCOCC>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[NH:21][C:22]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:23]

참가 물질

4

반응물 2

HCID 1232391,3-Dichloro-2-isothiocyanatobenzeneHCID 27346391-Piperazinylpyrazine

생성물 1

HCID 20459211N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carbothioamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 6.12 g. of 2,6-dichlorophenyl isothiocyanate in 50 ml. of anhydrous ether over 10 minutes. The mixture is stirred for 15 minutes and the resulting solid collected. This solid is dissolved with heat in a mixture of 200 ml. of acetone and 150 ml. of methanol and then cooled. The resulting solid is collected giving 5.29 g. of the desired product as white crystals, m.p. 225°-227° C.

후처리

  1. customthe resulting solid collected
  2. dissolutionThis solid is dissolved
  3. temperaturewith heat in a mixture of 200 ml
  4. temperatureof methanol and then cooled
  5. customThe resulting solid is collected
  6. customgiving 5.29 g

출처 및 근거

ORD 기록
ord-6db896f2eea74c95ac7c2c0125c4e4f9
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450272

반응 노트

불러오는 중…