Quipazine → N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

HRID 544488노트

반응식

HRID 544488 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:17]([N:19]=[C:20]=[S:21])[CH3:18]>CCOCC>[CH2:17]([NH:19][C:20]([N:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[CH2:12][CH2:13]1)=[S:21])[CH3:18]

참가 물질

4

반응물 2

HCID 5011QuipazineHCID 10966Ethyl isothiocyanate

생성물 1

HCID 13318697N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a slurry of 4.26 g. of 1-(2-quinolinyl)piperazine in 30 ml. of anhydrousether is added dropwise a solution of 1.74 g. of ethyl isothiocyanate in 30ml. of anhydrous ether. The mixture is stirred for one hour and the resulting solid is collected and recrystallized from 150 ml. of ethanol, giving 4.43 g. of the desired product as a white crystalline solid, m.p. 193°-195° C.

후처리

  1. additionof anhydrousether is added dropwise a solution of 1.74 g
  2. customthe resulting solid is collected
  3. customrecrystallized from 150 ml
  4. customof ethanol, giving 4.43 g

출처 및 근거

ORD 기록
ord-326458202523403b945fdb1e247f5272
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450272

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