tert-Butyl isothiocyanate → N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide
반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:13]([N:17]=[C:18]=[S:19])([CH3:16])([CH3:15])[CH3:14]>CCOCC>[C:13]([NH:17][C:18]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:19])([CH3:16])([CH3:15])[CH3:14]참가 물질
4
실험 절차
To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 3.45 g. of tert-butyl isothiocyanate in 50 ml. of anhydrous ether. The mixture is stirred for 30minutes and the resulting solid is collected and recrystallized from 50 ml.of ethanol, giving 5.85 g. of the desired product as white crystals, m.p. 153°-156° C.
후처리
- customthe resulting solid is collected
- customrecrystallized from 50 ml
- customof ethanol, giving 5.85 g
출처 및 근거
- ORD 기록
- ord-a597b8511d76413fa3f7b9154a995282
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04450272
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