Water → 3-(5-Methyl-1,2-oxazol-3-yl)propan-1-ol
반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[O:12][N:11]=[C:10]([CH2:13][CH2:14][C:15](OC)=[O:16])[CH:9]=1.O>O1CCCC1>[CH3:7][C:8]1[O:12][N:11]=[C:10]([CH2:13][CH2:14][CH2:15][OH:16])[CH:9]=1참가 물질
5
실험 절차
To a suspension of 7.6 g of lithium aluminum hydride in 250 ml of tetrahydrofuran was added a solution of 64.9 g of methyl 5-methyl-3-isoxazolepropanoate in 100 ml of tetrahydrofuran. The reaction mixture was stirred at reflux for three hours, then cooled and 15.2 ml of water in 30 ml of tetrahydrofuran added. The mixture was filtered and the filtrate concentrated in vacuo. The residue was distilled to give 44.1 g of 5-methyl-3-(3-hydroxypropyl)isoxazole, b.p. 84°-85° C.(0.1 mm).
후처리
- temperatureat reflux for three hours
- temperaturecooled
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated in vacuo
- distillationThe residue was distilled
출처 및 근거
- ORD 기록
- ord-f0b07546b75240a6b9b127c8465d75a8
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04451476
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