4-Isopropylaniline → 4-Isopropylphenyl cyanamide
반응식
[N:1]#[C:2]Br.[CH:4]([C:7]1[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=1)([CH3:6])[CH3:5]>C(OCC)C>[CH:4]([C:7]1[CH:13]=[CH:12][C:10]([NH:11][C:2]#[N:1])=[CH:9][CH:8]=1)([CH3:6])[CH3:5]참가 물질
4
실험 절차
A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).
후처리
- additionAfter the addition
- stirringthe reaction mixture was kept stirring at room temperature for 18 h
- customThen a solution with white precipitates
- customformed
- customthe precipitates were removed by filtration
- washThe etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-d8ec55e141424ed1a7ead9eed3a444d6
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05622968
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