Methanethiol → 1-[5-(Methylsulfanyl)-4-nitrothiophen-2-yl]ethan-1-one
반응식
[CH3:1][SH:2].Cl[C:4]1[S:5][C:6]([C:12](=[O:14])[CH3:13])=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].O>C(O)C>[CH3:1][S:2][C:4]1[S:5][C:6]([C:12](=[O:14])[CH3:13])=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]참가 물질
5
실험 절차
Liquid methylmercaptan (4 ml) was added to a solution of 0.82 g of Na in 50 ml of absolute ethanol. The resulting solution was added to a solution of 7.2 g of 2-chloro-3-nitro-5-acetylthiophene in 200 ml of absolute ethanol in 15 minutes at 5° C. After stirring at room temperature for 30 minutes, 100 ml of water was added, after which the precipitate was sucked off and washed successively with water and isopropanol. The precipitate was boiled a moment with 300 ml of carbontetrachloride, cooled down, and sucked off. After drying the title compound was obtained in a yield of 6.4 g; m.p. 191°-193° C.
후처리
- washwashed successively with water and isopropanol
- temperaturecooled down
- dry with materialAfter drying the title compound
- customwas obtained in a yield of 6.4 g
출처 및 근거
- ORD 기록
- ord-ecb85c68df1b4eb9a34bd7c29ea0387b
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04451660
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