Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[4-[(methylamino) methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 반응물 | N-methyl-4-(3-pyrrolidinyl)benzenemethanamine | HCID 15288435 | — |
| 생성물 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[4-[(methylamino) methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 15288436 | 85% |
반응 단계
Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.80 g, 3.0 mmol) and N-methyl-4-(3-pyrrolidinyl)benzene-methanamine, a procedure analogous to that given in Example 1 provided the title compound (1.11 g, 85%) as an off-white solid, mp 235°-237° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622966 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-1852f2c77e5740aab35b1c6110db6dc1 |
| 출처 메모 | uspto-grants-1997_04 |