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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 544948생성일: 2026년 10월 25일

3-Bromo-4-methylbenzonitrile → 5-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

https://huagongshe.com/reaction/544948

반응식

참여 물질

역할이름HCID투입량
반응물3-Bromo-4-methylbenzonitrileHCID 14004840—
반응물5-(5-(Cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acidHCID 59761503—
생성물5-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamideHCID 67149011—

반응 단계

The title compound was prepared by coupling 5-(5-(cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acid (Example 210, Step A) with commercially available 2-bromo-4-cyanotoluene using the method described in Step B of Example 136 to afford a white solid after purification by reverse phase preparative HPLC (Example 213). HPLC Ret time=3.36 min. LCMS [M+H]+ 416.29.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07935696B2
출처 데이터셋uspto-grants-2011_05
ORD IDord-bd3898b72cae44d9b84337e4b89d05bc
출처 메모uspto-grants-2011_05