2-Chloro-3-(trifluoromethyl)pyridine → 2-Methoxy-3-(trifluoromethyl)pyridine

HRID 545068노트

반응식

HRID 545068 반응식
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 10942334Sodium Methoxide

생성물 1

HCID 27753092-Methoxy-3-(trifluoromethyl)pyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Heat a mixture of 2-chloro-3-trifluoromethyl-pyridine (1.8 g, 10 mmol) and sodium methoxide (4M, 5 mL, 20 mmol) in MeOH (20 mL) at reflux for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (50 mL) and wash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL). Dry the organic extract over MgSO4 and remove the solvent under reduced pressure to yield the title compound.

후처리

  1. temperatureHeat
  2. temperatureat reflux for 18 hours
  3. temperatureCool the mixture
  4. customremove the volatiles
  5. customby rotary evaporation
  6. dissolutionDissolve the residue in EtOAc (50 mL)
  7. washwash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL)
  8. customDry the
  9. extractionorganic extract over MgSO4
  10. customremove the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-7dceeb3bdea34bc9b81ebf9dac1ee8d5
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935702B2

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