Phenyltrimethylammonium bromide dibromide → 2-Bromo-1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

HRID 545090노트

반응식

HRID 545090 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[C:5]([C:8](=[O:10])[CH3:9])=[N:6][CH:7]=1.[Br-:15].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:15][CH2:9][C:8]([C:5]1[C:4]([C:11]([F:14])([F:12])[F:13])=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)=[O:10]

참가 물질

4

반응물 2

HCID 17977687Phenyltrimethylammonium bromide dibromideHCID 586455621-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

생성물 1

HCID 866051072-Bromo-1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dissolve 1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone (0.7 g, 0.0026 mol) in anhydrous THF at room temperature under N2 atmosphere. Add phenyltrimethyl-ammonium tribromide (1.47 g, 0.0039 moles, 1.5 eq.) to the reaction mixture and reflux overnight. Cool the reaction mixture to room temperature, filter the insoluble solid and concentrate the filtrate under vacuum. Purify by column chromatography to afford the title compound as a yellow oil.

후처리

  1. filtrationfilter the insoluble solid
  2. concentrationconcentrate the filtrate under vacuum
  3. customPurify by column chromatography

출처 및 근거

ORD 기록
ord-663cd03b059e4557847927ba69c5b95b
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935702B2

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