Sodium Bicarbonate → 6-(8-Chloropyrido[2,3-b]pyrazin-3-yl)-5-(trifluoromethyl)nicotinamide

HRID 545094노트

반응식

HRID 545094 반응식
O[CH:2](O)[C:3]([C:5]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=1)=O.[Cl:19][C:20]1[CH:25]=[CH:24][N:23]=[C:22]([NH2:26])[C:21]=1[NH2:27].C([O-])(O)=O.[Na+]>CCO>[Cl:19][C:20]1[C:21]2[C:22](=[N:26][C:3]([C:5]3[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=3)=[CH:2][N:27]=2)[N:23]=[CH:24][CH:25]=1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 224180044-Chloropyridine-2,3-diamineHCID 671896796-(2,2-Dihydroxyacetyl)-5-(trifluoromethyl)nicotinamide

생성물 1

HCID 671914016-(8-Chloropyrido[2,3-b]pyrazin-3-yl)-5-(trifluoromethyl)nicotinamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolve 6-(2,2-dihydroxyacetyl)-5-(trifluoromethyl)nicotinamide (8.0 g) in 100.0 mL of EtOH and then add 4-chloro-2,3-diaminopyridine (800 mg) followed by addition of NaHCO3 (3.6 g). Stir the reaction at room temperature for 18 hours under N2 atmosphere. Concentrate the reaction mixture under vacuum, and purify by column chromatography to afford the title product as a yellow solid.

후처리

  1. customthe reaction at room temperature for 18 hours under N2 atmosphere
  2. concentrationConcentrate the reaction mixture under vacuum
  3. custompurify by column chromatography

출처 및 근거

ORD 기록
ord-5cc52d70bbfa4d979ed3c1009b47bef5
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935702B2

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