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Ethanol → (2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide hydrochloride

HRID 545104
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인쇄 미리보기

반응식

HRID 545104 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14](=[O:17])[CH2:15][Cl:16])[CH2:7]1.C(OCC)(=O)C.Cl.C(O)C>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14](=[O:17])[CH2:15][Cl:16])[CH2:7]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 702EthanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 57686783(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide

생성물 1

HCID 67169608(2S)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}chloroacetamide hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The resultant product (31.0 g) of (1-1) was dissolved in ethyl acetate (100 mL), and a 4 mol/L hydrogen chloride-ethyl acetate solution (22.5 mL) was added dropwise under ice-cooling. Ethanol was further added for dissolution, and the mixture was left standing overnight and the resulting solid was collected by filtration, washed with ethyl acetate, and dried to give the title compound (29.8 g) as white crystals.

후처리

  1. temperaturecooling
  2. waitthe mixture was left
  3. filtrationthe resulting solid was collected by filtration
  4. washwashed with ethyl acetate
  5. customdried

출처 및 근거

ORD 기록
ord-d171954690e7498b937d5f518a3be831
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07935700B2

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