Thionyl Chloride → 1-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

HRID 54514

반응식

HRID 54514 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8](O)[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[N:6][CH:7]=1.S(Cl)([Cl:18])=O>C1(C)C=CC=CC=1>[Cl:18][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 19959418HCID 19959418, 화합물

생성물 1

HCID 199594231-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1 g of 1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane-1-ol is dissolved in 2 ml of toluene, 6 ml of thionyl chloride are added and the reaction mixture is stirred for 30 minutes at room temperature. The solvent and the thionyl chloride in excess are distilled off, the residue is dissolved in 2N NaOH, extracted with ethyl acetate, dried over Na2SO4 and evaporated to yield the compound as a colourless oil.

후처리

  1. distillationThe solvent and the thionyl chloride in excess are distilled off
  2. dissolutionthe residue is dissolved in 2N NaOH
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-3294db1eb1ce4e988dd4e58e736a0c00
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622982

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