Dimethylformamide → N-(4'-Chlorobiphenyl-4-carbonyl)-2(R)-phenyl-aziridine

HRID 54518

반응식

HRID 54518 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17]1(N2CC2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:26][N:27]([CH:29]=O)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([N:27]3[CH2:29][C@H:26]3[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:16])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 6228Dimethylformamide2회HCID 696731-PhenylaziridineHCID 6160024-Biphenylcarboxylic acid, 4'-chloro-

생성물 1

HCID 22872208N-(4'-Chlorobiphenyl-4-carbonyl)-2(R)-phenyl-aziridine

실험 절차

To a solution of 0.232 g of 4'-chlorobiphenyl-4-carboxylic acid in 3 ml of dry DMF, 0.18 g of N,N'-carbonyl-diimidazole are added with stirring at room temperature under argon atmosphere. After one hour a solution of 0.12 g of phenyl-aziridine in 0.5 ml of dry DMF is added dropwise. The reaction mixture is stirred for 21 hours and thereafter worked up as described in example 1. The compound is obtained as a pale yellow oil and used without purification in the next step.

후처리

  1. stirringThe reaction mixture is stirred for 21 hours
  2. customThe compound is obtained as a pale yellow oil
  3. customused without purification in the next step

출처 및 근거

ORD 기록
ord-50be94b7d1fa41d4856b0969252a7d2c
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622982

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