Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Epoxy-3-fluoropropane | HCID 10418 | — |
| 반응물 | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol | HCID 67171089 | 43.9% |
반응 단계
Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07935708B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-d7023ffab59d484ebf7ad48ae95afa9f |
| 출처 메모 | uspto-grants-2011_05 |