1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol

HRID 545238

반응식

HRID 545238 반응식
[CH2:1]([CH:3]1[O:5][CH2:4]1)[F:2].[N+:6]([C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:11][CH:10]=1)([O-:8])=[O:7]>C(O)C>[F:2][CH2:1][CH:3]([OH:5])[CH2:4][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([N+:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[CH2:16][CH2:17]1

참가 물질

4

반응물 2

HCID 104181,2-Epoxy-3-fluoropropaneHCID 804471-(4-Nitrophenyl)piperazine

생성물 1

HCID 671710891-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol수율 43.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.

후처리

  1. temperatureunder reflux for 15 hours
  2. customthe reaction liquid
  3. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d7023ffab59d484ebf7ad48ae95afa9f
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935708B2

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