4-(Quinolin-2-ylmethoxy)benzyl alcohol → 2-(4-Chloromethylphenoxy)methylquinoline
반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]O)=[CH:15][CH:14]=1.[Cl:21]C1C=C2C(C=CC(COC3C=CC(CO)=CC=3)=N2)=CC=1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][Cl:21])=[CH:15][CH:14]=1참가 물질
3
실험 절차
The procedure from Example 6, part B was used except 4-(quinolin-2-ylmethoxy)benzyl alcohol was substituted for 4-(7-chloroquinolin-2-ylmethoxy)benzyl alcohol. The intermediate was obtained in 47% yield.
후처리
- customThe intermediate was obtained in 47% yield
출처 및 근거
- ORD 기록
- ord-43a1e498f73c49d4ad930a4bcb5a4155
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05622969
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