Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → Ethyl 2-amino-2-(4-fluorobenzoyloxyimino)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 4-Fluorobenzoic Acid | HCID 9973 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Ethyl 2-amino-2-(hydroxyimino)acetate | HCID 6785548 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 2-amino-2-(4-fluorobenzoyloxyimino)acetate | HCID 54483830 | 88.2% |
반응 단계
To a mixture of 4-fluorobenzoic acid (2.0 g), ethyl 2-amino-2-hydroxyiminoacetate (2.07 g) and 4-dimethylaminopyridine (0.52 g) in methylene chloride (30 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (2.87 ml) at 0° C. under stirring. After stirring at ambient temperature for 1 hour, diethyl ether (10 ml) was added thereto and the resulting precipitate was filtered off, washed with diethyl ether, and dried in vacuo to give ethyl 2-amino-2-(4-fluorobenzoyloxyimino)acetate (3.2 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622976 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-2c9c36b844f840168efb45e7c85bf2f9 |
| 출처 메모 | uspto-grants-1997_04 |