[2-(3-Hexyl-phenyl)-5-(3-hydroxy-prop-1-ynyl)-3-methyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone → HCID 57541077, 화합물

HRID 545393노트

반응식

HRID 545393 반응식
[CH2:1]([C:7]1[CH:8]=[C:9]([C:13]2[N:17]([CH3:18])[C:16]([C:19]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[C:15]([C:32]#[C:33][CH2:34][OH:35])[N:14]=2)[CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]>[Pt]=O>[CH2:1]([C:7]1[CH:8]=[C:9]([C:13]2[N:17]([CH3:18])[C:16]([C:19]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[C:15]([CH2:32][CH2:33][CH2:34][OH:35])[N:14]=2)[CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

3

반응물 1

HCID 57541113[2-(3-Hexyl-phenyl)-5-(3-hydroxy-prop-1-ynyl)-3-methyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

생성물 1

HCID 57541077HCID 57541077, 화합물

시약·촉매·용매 1

HCID 82844Platinum oxide (PtO)촉매

실험 절차

In analogy to the procedure described for example 14, [2-(3-hexyl-phenyl)-5-(3-hydroxy-prop-1-ynyl)-3-methyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 31) was hydrogenated using platinum oxide as catalyst to give the title compound as yellow oil. MS: 481.4 (MH+).

출처 및 근거

ORD 기록
ord-736fb6932941417a89e80d9dd9f94346
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935707B2

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