Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride → [2-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-[4-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | ((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride | HCID 67133026 | — |
| 반응물 | 2-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazole-4-carboxylic acid | HCID 67133239 | — |
| 생성물 | [2-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-[4-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone | HCID 57541141 | — |
반응 단계
In analogy to the procedure described for example 2, 2-(3-hexyl-phenyl)-5-iodo-3-methyl-3H-imidazole-4-carboxylic acid (intermediate 1) and ((R)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride (intermediate 2) gave the title compound as light red amorphous solid. MS: 579.3 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07935707B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-8644913ba96e4da29633a33912dcbc58 |
| 출처 메모 | uspto-grants-2011_05 |