Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Diethyl (cyanomethyl)phosphonate | HCID 75676 | — |
| 반응물 | 1-Benzylpiperidine-4-carbaldehyde | HCID 89584 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile | HCID 19959219 | 109.8% |
반응 단계
A solution of 1-benzyl-4-formylpiperidine (4.5 g) in tetrahydrofuran (20 ml) was added dropwise to a suspension of diethyl cyanomethylphosphonate (4.31 g) and sodium hydride (0.97 g, 60% suspension in oil) in tetrahydrofuran (30 ml) at 0° C. under stirring. After stirring for 1 hour at ambient temperature, the mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and brine and dried over magnesium sulfate, and evaporated in vacuo to give (E)-3-(1-benzylpiperidin-4-yl)-2-propenenitrile (5.5 g) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622976 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-24d05c94f6b3425fbf94f5419890062f |
| 출처 메모 | uspto-grants-1997_04 |