반응식
C(O[C:4]([C:6]1[N:10]=[C:9]([CH:11]2[CH:16]3[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]3)[CH2:12]2)[O:8][N:7]=1)=[O:5])C.[CH2:19]([N:26]1[CH2:31][CH2:30][CH:29]([CH2:32][CH2:33][NH2:34])[CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[N:13]12[CH2:14][CH2:15][CH:16]([CH2:17][CH2:18]1)[CH:11]([C:9]1[O:8][N:7]=[C:6]([C:4](=[O:5])[NH:34][CH2:33][CH2:32][CH:29]3[CH2:28][CH2:27][N:26]([CH2:19][C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:31][CH2:30]3)[N:10]=1)[CH2:12]2참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 3-ethoxycarbonyl-5-(quinuclidin-3-yl)-1,2,4-oxadiazole (0.2 g) and 1-benzyl-4-(2-aminoethyl)piperidine (0.26 g) was stirred and heated at 100° C. for 2 hours. The cooled mixture was chromatographed on alumina eluting with chloroform to give 5-(quinuclidin-3-yl)-3-[{2-(1-benzylpiperidin-4-yl)ethyl}carbamoyl]-1,2,4-oxadiazole as an oil. The compound was treated with an ethanol solution of hydrogen chloride, the solution was evaporated in vacuo and the residue was powdered with ether to give 5-(quinuclidin-3-yl)-3-[{2-(1-benzylpiperidin-4-yl)ethyl}carbamoyl]-1,2,4-oxadiazole dihydrochloride (0.2 g).
후처리
- customThe cooled mixture was chromatographed on alumina eluting with chloroform
출처 및 근거
- ORD 기록
- ord-f63717e5f49849a488f00827e3ebbd54
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05622976
연결된 노트
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