Acetyl chloride → 1-(2,3-Dihydro-5-benzofuranyl)ethanone

온도

0 °C

To a 0° C. solution of acetyl chloride (1.64 mL, 23.0 mmol, 1.3 equivalents) in methylene chloride (30 mL) was added stannic chloride (2.49 mL. 21.3 mmol, 1.2 equivalents), maintaining the temperature below 5° C. The solution was stirred 15 minutes at 0° C., and then a solution of 2,3-dihydrofuran (2.00 mL, 17.7 mmol) in methylene chloride (5 mL) was added dropwise while maintaining the temperature below 8° C. The dark red solution was stirred 1 hour at 2° C. and then poured into 50 mL of ice water. The reaction was stirred an additional 30 minutes, and the layers were separated. The organic layer was washed with water and aqueous sodium bicarbonate, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography on 150 g silica gel, eluting with 18% ethyl acetate in hexanes. The solvents were removed under reduced pressure to yield the title compound (2.68 g, 93%) as a yellow solid.

1. temperaturemaintaining the temperature below 5° C
2. temperaturewhile maintaining the temperature below 8° C
3. stirringThe dark red solution was stirred 1 hour at 2° C.
4. stirringThe reaction was stirred an additional 30 minutes
5. customthe layers were separated
6. washThe organic layer was washed with water and aqueous sodium bicarbonate
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure
10. customThe residue was purified by flash chromatography on 150 g silica gel
11. washeluting with 18% ethyl acetate in hexanes
12. customThe solvents were removed under reduced pressure

ORD 기록

ord-f5e458cfdfde4895ab2d263d23f2ef1e

출처 데이터셋

uspto-grants-1997_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05622971