3-(5-bromo-2-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one → 3-(5-bromo-2-hydroxyphenyl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one
반응식
FC1C=C2C(=CC=1)N(C[C:12]1[O:13]C(C(F)(F)F)=CC=1)C(=O)C2C1C(O)=CC2OCOC=2C=1.[Br:32][C:33]1[CH:34]=[CH:35][C:36]([OH:49])=[C:37]([CH:39]2[C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[NH:41][C:40]2=[O:48])[CH:38]=1>>[Br:32][C:33]1[CH:34]=[CH:35][C:36]([OH:49])=[C:37]([C:39]2([CH2:12][OH:13])[C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[NH:41][C:40]2=[O:48])[CH:38]=1참가 물질
3
실험 절차
Following the procedure as described in PREPARATION 35D, and making non-critical variations to replace 5-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one with 3-(5-bromo-2-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one, the title compound was obtained: MS (ES+) m/z 334.2 (M+1), 336.2 (M+1).
출처 및 근거
- ORD 기록