Water → 2-(3-Nitrobenzylidene)-3,4-dihydronaphthalen-1(2h)-one

HRID 54586

반응식

HRID 54586 반응식
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[N+:12]([C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH:18]=O)([O-:14])=[O:13].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[N+:12]([C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH:18]=[C:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1]1=[O:11])([O-:14])=[O:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 74493-NitrobenzaldehydeHCID 107241-TetraloneHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 2888042-(3-Nitrobenzylidene)-3,4-dihydronaphthalen-1(2h)-one

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 3,4-dihydro-1(2H)-naphthalenone (21.9 g), 3-nitrobenzaldehyde (22.6 g) and p-toluenesulphonic acid monohydrate (50 mg) in toluene (250 ml) was stirred at reflux with separation of water for 4.5 hours. The brown solution was allowed to cool overnight. The resulting yellow-orange deposited solid was filtered off, washed well with toluene and dried in vacuo yielding 2-(3-nitrobenzylidene)-3,4-dihydro-1(2H)-naphthalenone as crisp yellow needles.

후처리

  1. temperatureto cool overnight
  2. filtrationwas filtered off
  3. washwashed well with toluene
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-24bd5505bcae4988aed129c6132f0ea9
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622987

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