Iodine → 2-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol

HRID 54625

반응식

HRID 54625 반응식
[CH2:1]([C:4]1[C:5](=[O:18])[CH:6]=[C:7]([CH:15]([CH3:17])[CH3:16])[C:8](=[O:14])[C:9]=1[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:2][CH3:3].C[SiH](C)O[SiH](C)C.II>C(Cl)Cl>[CH2:1]([C:4]1[C:9]([C:10]([CH3:12])([CH3:11])[CH3:13])=[C:8]([OH:14])[C:7]([CH:15]([CH3:17])[CH3:16])=[CH:6][C:5]=1[OH:18])[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 807IodineHCID 186591,1,3,3-Tetramethyl-disiloxaneHCID 570664232-Propyl-3-t-butyl-5-isopropylbenzoquinone

생성물 1

HCID 540178862-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dissolve 2-propyl-3-t-butyl-5-isopropylbenzoquinone (10 mmol), 1,1,3,3-tetramethyldisiloxane (1.79 mL, 10 mmol) and iodine (0.05 g) in methylene chloride (30 mL). Stir at reflux for 30 minutes and extract with 1N sodium hydroxide (30 mL). Acidify the aqueous phase with concentrated hydrochloric acid and extract into ethyl acetate (4×10 mL), dry (Na2SO4) and evaporate the solvent in vacuo to give 2-propyl-3-t-butyl-4-hydroxy-5-isopropylphenol.

후처리

  1. temperatureat reflux for 30 minutes
  2. extractionextract with 1N sodium hydroxide (30 mL)
  3. extractionextract into ethyl acetate (4×10 mL)
  4. dry with materialdry (Na2SO4)
  5. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-74f40ec81bdb4a25a8b6d066a07b9c93
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623052

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