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Acetic Acid → N-Ethylcarbamate 5-cyclopropylmethoxy-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

HRID 546316
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HRID 546316 반응식
C1C(=O)N([Cl:8])C(=O)C1.C(O)(=O)C.[CH2:13]([NH:15][C:16](=[O:18])[O-:17])[CH3:14].[CH:19]1([CH2:22][O:23][C:24]2[CH:25]=[CH:26][C:27]3[CH:28]([CH3:36])[CH:29]4[CH2:33][NH:32][CH2:31][CH:30]4[C:34]=3[CH:35]=2)[CH2:21][CH2:20]1>ClCCCl>[CH2:13]([NH:15][C:16](=[O:17])[O-:18])[CH3:14].[CH:19]1([CH2:22][O:23][C:24]2[C:25]([Cl:8])=[CH:26][C:27]3[CH:28]([CH3:36])[CH:29]4[CH2:33][NH:32][CH2:31][CH:30]4[C:34]=3[CH:35]=2)[CH2:20][CH2:21]1
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5

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HCID 176Acetic AcidHCID 31398ChlorosuccinimideHCID 86602865N-Ethylcarbamate 5-cyclopropylmethoxy-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

생성물 1

HCID 86602866N-Ethylcarbamate 5-cyclopropylmethoxy-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

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온도
70 °C

실험 절차

NCS (38 mg, 0.28 mmol) and acetic acid (1 mL) were added to a solution of N-ethylcarbamate-5-cyclopropylmethoxy-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole (89 mg, 0.28 mmol) in DCE (2 mL), and the reaction solution was stirred for 3 hours at 70° C. The reaction was quenched with H2O and the solution filtered through an Extrelut column. The column was washed with CH2Cl2, and the filtrate was concentrated. The subtitle compound was obtained without further purification. MS calculated for C19H24ClNO3+H: 350, observed: 350.

후처리

  1. customThe reaction was quenched with H2O
  2. filtrationthe solution filtered through an Extrelut column
  3. washThe column was washed with CH2Cl2
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9488ffa27d5641c5a88f7c8568776c25
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07935830B2

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