Sodium Carbonate → 4-Oxo-2-nonenal

HRID 546355노트

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HRID 546355 반응식
[CH2:1]([C:6]1[O:7][CH:8]=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH3:5].ClC1C=CC=C(C(OO)=[O:19])C=1.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[O:19]=[C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])/[CH:10]=[CH:9]/[CH:8]=[O:7]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 196022-PentylfuranHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 64455374-Oxo-2-nonenal수율 73%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.0 g (14.47 mmol) of 2-pentylfuran was dissolved in 60 ml of dichloromethane, and 3.84 g (14.47 mmol) of 65% m-chloroperbenzoic acid was added dropwise thereto with stirring under ice-cooling, followed by stirring for 1 hour at the same temperature. To the reaction solution was added saturated aqueous sodium carbonate and the mixture was extracted with dichloromethane. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and was then concentrated under reduced pressure to give 1.62 g of the title compound as a yellow oil (yield: 73%).

후처리

  1. temperaturecooling
  2. stirringby stirring for 1 hour at the same temperature
  3. extractionthe mixture was extracted with dichloromethane
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationwas then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-efd4299953bf4ed4b9c7d8ba225cc5fe
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935835B2

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