Methyl 3-chloro-4-fluoro-alpha-azidocinnamate → Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

HRID 546405노트

반응식

HRID 546405 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[CH:5]=[C:6]([N:11]=[N+]=[N-])[C:7]([O:9][CH3:10])=[O:8]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][C:16]=1[F:17])[NH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5]2

참가 물질

3

반응물 1

HCID 54554773Methyl 3-chloro-4-fluoro-alpha-azidocinnamate

생성물 1

HCID 18986230Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A mixture of methyl 3-chloro-4-fluoro-α-azidocinnamate (Japanese Patent Application Laid-Open No. 149723/1995) (1.85 g) and xylene (140 ml) was heated under reflux for 1 hour, and the solvent was then distilled off. The residue was purified by column chromatography on silica gel (dichloromethane) to obtain the title compound (491 mg) as colorless powder.

후처리

  1. temperatureunder reflux for 1 hour
  2. distillationthe solvent was then distilled off
  3. customThe residue was purified by column chromatography on silica gel (dichloromethane)

출처 및 근거

ORD 기록
ord-a3e5e9f52c684f409454aa374302f0c5
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935824B2

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