Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(1-(3-(Trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Hydrazinecarboxylic acid, ethyl ester | HCID 20064 | — |
| 반응물 | 3'-(Trifluoromethyl)acetophenone | HCID 67682 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(1-(3-(Trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylic acid ethyl ester | HCID 54412625 | 100% |
반응 단계
m-Trifluoromethylacetophenone (74 g, 0.394 mole), ethyl carbazate (43 g, 0.413 mole), and catalytic p-toluenesulfonic acid (20 mg) were refluxed under N2 over a Dean-Stark trap in toluene (1.2 L) until the theoretical amount of water of reaction was removed (7.1 mL, 6 h). The solvent was then removed in vacuo and 2-(1-(3-(trifluoromethyl)phenyl)ethylidene)hydrazinecarboxylic acid ethyl ester (107 g, 100% yield) was obtained as a white solid which was recrystallized from cyclohexane, mp=94°-96° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05623072 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-ccecdd3cd98e4bafa7a846607a35e3de |
| 출처 메모 | uspto-grants-1997_04 |