Sodium Sulfite → 4-(4-Methoxycarbonylphenyl)pyridine N-oxide

HRID 546490노트

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HRID 546490 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:25])C=1.S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[CH3:14][O:13][C:11]([C:10]1[CH:15]=[CH:16][C:7]([C:4]2[CH:5]=[CH:6][N+:1]([O-:25])=[CH:2][CH:3]=2)=[CH:8][CH:9]=1)=[O:12]

참가 물질

5

반응물 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 5152686Methyl 4-(4-pyridinyl)benzoate

생성물 1

HCID 186176494-(4-Methoxycarbonylphenyl)pyridine N-oxide수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 4-(4-pyridyl)benzoate (1.49 g) was dissolved in dichloromethane (30 ml), 70% m-chloroperbenzoic acid (3.46 g) was added, and the mixture was stirred at room temperature for 1 hour. An aqueous solution of sodium sulfite was added to conduct liquid separation. The resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the title compound (1.33 g) as white powder.

후처리

  1. customliquid separation
  2. washThe resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-b0c781d1b1954b4b9ce6ae30e8951e6e
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935824B2

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