Water → HCID 68907744, 화합물

HRID 546512노트

반응식

HRID 546512 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([NH:14][C@@H:15]1[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]1[NH2:21])=[O:13])=[CH:6]2.C(N(CC)CC)C.[S:29]1[CH:33]=[CH:32][CH:31]=[C:30]1[S:34](Cl)(=[O:36])=[O:35].O>CN(C)C=O>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([NH:14][C@@H:15]1[CH2:20][CH2:19][CH2:18][CH2:17][C@@H:16]1[NH:21][S:34]([C:30]1[S:29][CH:33]=[CH:32][CH:31]=1)(=[O:36])=[O:35])=[O:13])=[CH:6]2

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 855182-Thiophenesulfonyl chlorideHCID 18442849HCID 18442849, 화합물

생성물 1

HCID 68907744HCID 68907744, 화합물수율 74.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(±)-cis-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride (200 mg) was dissolved in N,N-dimethylformamide (1 ml), and triethylamine (0.28 ml) and 2-thiophenesulfonyl chloride (111 mg) were added to stir the mixture for 75 minutes. Water was added to the reaction mixture, and deposit was collected by filtration and recrystallized from methanol to obtain the title compound (198 mg) as colorless crystals.

후처리

  1. filtrationwas collected by filtration
  2. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-f886d4e61323422da78eb83f8d9f3e0e
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935824B2

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