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HRID 546594생성일: 2026년 10월 25일

Cyclohexylamine → 1-(4-{[3-(4-Tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-cyclohexylurea

https://huagongshe.com/reaction/546594

반응식

참여 물질

역할이름HCID투입량
반응물CyclohexylamineHCID 7965—
반응물3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dioneHCID 57625975—
용매EthanolHCID 702—
생성물1-(4-{[3-(4-Tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-cyclohexylureaHCID 67197459—

반응 단계

This compound may be prepared as obtained in stage c) of Example 9, but starting with 200 mg of 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-thioxo-2H-[1,2,4]oxadiazolo[2,3-a]pyridin-7-yl)methyl]imidazolidine-2,4-dione obtained in stage b) of Example 9, 4 mL of ethanol and 56 mg of cyclohexanamine. After chromatography on a column of silica, eluting with a mixture of heptane/ethyl acetate (gradient from 100/0 to 0/100 by volume), 92 mg of 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl]methyl}pyridin-2-yl)-3-cyclohexylurea are obtained in the form of a pale yellow powder, the characteristics of which are as follows:

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07935819B2
출처 데이터셋uspto-grants-2011_05
ORD IDord-04defecd8429463eafebd63974b59c0c
출처 메모uspto-grants-2011_05