Ethyl Acetate → HCID 86628503, 화합물

HRID 546664노트

반응식

HRID 546664 반응식
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH2:55][OH:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1.C(OCC)(=O)C.O.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH:55]=[O:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 159087TriacetoxyperiodinaneHCID 66839396(8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanolHCID 86585896Sodium bicarbonate water

생성물 1

HCID 86628503HCID 86628503, 화합물수율 138.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dess-Martin periodinane (304 mg) was added to a solution of (8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol (165 mg) in methylene chloride (10 mL), and the reaction solution was stirred in a nitrogen atmosphere at room temperature for four hours. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 227 mg of the title compound. The property value of the compound is as follows.

후처리

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ae5115b819604094a7146598cc72f466
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935815B2

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