tert-butyl 4-[1-(N'-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate → Tert-butyl 4-[4-chloro-1-hydrazinocarbonyl-butan-1-yl]piperidine-1-carboxylate

HRID 546709노트

반응식

HRID 546709 반응식
C(OC([NH:11][NH:12][C:13]([CH:15]([CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1)[CH2:16][CH2:17][CH2:18][Cl:19])=[O:14])=O)C1C=CC=CC=1>CO.[C].[Pd]>[Cl:19][CH2:18][CH2:17][CH2:16][CH:15]([CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1)[C:13]([NH:12][NH2:11])=[O:14]

참가 물질

4

반응물 1

HCID 66839389tert-butyl 4-[1-(N'-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate

생성물 1

HCID 66839238Tert-butyl 4-[4-chloro-1-hydrazinocarbonyl-butan-1-yl]piperidine-1-carboxylate수율 100.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

10% palladium-carbon (50% wet, 200 mg) was added to a solution of tert-butyl 4-[1-(N′-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate (928 mg) in methanol (15 ml), and the reaction solution was hydrogenated at normal pressure at room temperature for 4.5 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure to obtain 663 mg of the title compound. The property value of the compound is as follows.

후처리

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7042997d60f54e6b9e6befd6f63572e1
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935815B2

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