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Ethanol → HCID 66839470, 화합물

HRID 546769
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인쇄 미리보기

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HRID 546769 반응식
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]#N.Cl[Si](C)(C)C.C(=O)([O-])[O-:20].[K+].[K+].O.[CH2:26]([OH:28])[CH3:27]>C(OCC)(=O)C>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([O:28][CH2:26][CH3:27])=[O:20]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 702EthanolHCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 11430Potassium CarbonateHCID 27370162-(Difluoromethoxy)phenylacetonitrile

생성물 1

HCID 66839470HCID 66839470, 화합물

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매

반응 조건

온도
50 °C

실험 절차

(2-Difluoromethoxyphenyl)acetonitrile (1.45 g) was added dropwise to a solution of chlorotrimethylsilane (2.23 mL) in ethanol (2.0 mL), and the reaction solution was stirred at 50° C. for five hours. The reaction solution was left to cool to room temperature. Then, potassium carbonate, water and ethyl acetate were added and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 620 mg of the title compound. The property values of the compound are as follows.

후처리

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. customthe organic layer was separated
  4. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system)

출처 및 근거

ORD 기록
ord-a1dca4d0d8664b5c9325286960b33dd2
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07935815B2

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