4-Fluoro-3-methylphenylacetonitrile → 2-(4-Fluoro-3-methylphenyl)acetamide

HRID 546774노트

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HRID 546774 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[CH3:11].C[Si](C)(C)[O:14][K].O.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:10])=[O:14])=[CH:4][C:3]=1[CH3:11]

참가 물질

5

반응물 3

HCID 201118384-Fluoro-3-methylphenylacetonitrileHCID 86585896Sodium bicarbonate waterHCID 178504318HCID 178504318, 화합물

생성물 1

HCID 668394032-(4-Fluoro-3-methylphenyl)acetamide수율 70%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
110 °C

실험 절차

4-Fluoro-3-methylphenylacetonitrile (1.1 g) was dissolved in toluene (35 ml), and trimethylsiloxypotassium (3.7 g) was added. After stirring at 110° C. for 2.5 hours, saturated sodium bicarbonate water was added, followed by separation with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to obtain 863 mg of the title compound. The property values of the compound are as follows.

후처리

  1. customfollowed by separation with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-11ced35569554d9dae2da493e6af642b
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935815B2

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