p-Bromoacetophenone → 2-(4-Bromophenyl)propan-2-ol

HRID 546822

반응식

HRID 546822 반응식
[CH3:1][Li].[CH3:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)=[O:5].[Cl-].[NH4+]>O1CCCC1>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]([OH:5])([CH3:1])[CH3:3])=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 7466p-BromoacetophenoneHCID 25517Ammonium ChlorideHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 126819202-(4-Bromophenyl)propan-2-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyllithium (1.10 mol/l solution in diethyl ether, 502 mL, 0.552 mol) was added to a solution of 4-bromoacetophenone (100 g, 0.502 mol) in tetrahydrofuran (500 mL) in a nitrogen atmosphere at −78° C., and the mixture was stirred at the same temperature for one hour. The reaction mixture was poured into a saturated aqueous ammonium chloride solution, followed by extraction with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give crude 2-(4-bromo-phenyl)-propan-2-ol.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-ae60c4c0673d4a18a150ebdc63f44cd6
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

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