Ammonium Chloride → 1-(3-Bromophenyl)-2,2-dimethylpropan-1-ol

HRID 546831노트

반응식

HRID 546831 반응식
[C:1]([Mg]Cl)([CH3:4])([CH3:3])[CH3:2].[Br:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH:11]=[O:12].[Cl-].[NH4+]>O1CCCC1>[Br:7][C:8]1[CH:9]=[C:10]([CH:11]([OH:12])[C:1]([CH3:4])([CH3:3])[CH3:2])[CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 765833-BromobenzaldehydeHCID 178418310HCID 178418310, 화합물

생성물 1

HCID 574434831-(3-Bromophenyl)-2,2-dimethylpropan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

t-Butylmagnesium chloride (0.93 mol/l solution in tetrahydrofuran, 75.5 mL, 70.26 mmol) was added to a solution of 3-bromobenzaldehyde (10 g, 54.05 mmol) in tetrahydrofuran (100 mL) in a nitrogen atmosphere at −78° C. The mixture was stirred at the same temperature for one hour and then heated to room temperature. The reaction mixture was poured into a saturated aqueous ammonium chloride solution, followed by extraction with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate and filtered, and the solvent was distilled off under reduced pressure to give crude 1-(3-bromo-phenyl)-2,2-dimethyl-propan-1-ol.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-25a0da022fc04485a7bd82c0bcbed3fc
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

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