Ammonium Hydroxide → 2-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

HRID 54690노트

반응식

HRID 54690 반응식
[OH-].[NH4+].Br.Br.[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1>>[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 190408002-(2-Hydroxyethylamino)-1-phenacylbenzimidazole dihydrobromide

생성물 1

HCID 28501002-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

실험 절차

Add 22% ammonium hydroxide to 75 ml of a hot solution of the dihydrobromide obtained in Step A in 95° alcohol until a pH of approximately 10 is obtained. The title compound precipitates and is filtered, washed with water and dried.

후처리

  1. customis obtained
  2. customThe title compound precipitates
  3. filtrationis filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-31389e86c4f54555a7926b88794f66ba
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623073

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