Acetic Acid → (3-chloro-5-fluoro-phenyl)-acetic Acid Methyl Ester

HRID 547028노트

반응식

HRID 547028 반응식
C[Si](C=[N+]=[N-])(C)C.[Cl:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([OH:19])=[O:18])[CH:12]=[C:13]([F:15])[CH:14]=1.[C:20](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:20][O:18][C:17](=[O:19])[CH2:16][C:11]1[CH:12]=[C:13]([F:15])[CH:14]=[C:9]([Cl:8])[CH:10]=1

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 27348372-(3-Chloro-5-fluorophenyl)acetic acid

생성물 1

HCID 57443518(3-chloro-5-fluoro-phenyl)-acetic Acid Methyl Ester수율 99%

시약·촉매·용매 2

HCID 887Methanol용매HCID 1140Toluene용매

실험 절차

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.199 mL, 0.398 mmol) was added to a solution of (3-chloro-5-fluoro-phenyl)acetic acid (50 mg, 0.265 mmol) in methanol (0.5 mL) and toluene (2 mL), and the mixture was stirred at room temperature for 10 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (53 mg, 99%).

후처리

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-39cb5eed227e4ff6b2ea509c8be8ddc8
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935688B2

반응 노트

불러오는 중…