Bromine → 2-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

HRID 54703

반응식

HRID 54703 반응식
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].BrBr.[NH2:12][C:13]1[N:17]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:16]2[CH:26]=[CH:27][CH:28]=[CH:29][C:15]=2[N:14]=1>CC(C)=O>[Br-:1].[NH2:12][C:13]1[N:14]([CH2:2][C:3](=[O:4])[C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[N+:17]=1[CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

5

반응물 3

HCID 24408BromineHCID 5665591-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amineHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

생성물 1

HCID 1785085292-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

An ethereal solution of 2-bromoacetylthiophene (obtained by brominating 2-acetylthiophene (1.9 g, 15 mmol) with 0.8 ml (15 mmol) of bromine in 10 ml of dioxane and 15 ml of ether) is added to a hot solution of 2-amino-1-(2-piperidinoethyl)benzimidazole (2.44 g; 10 mmol) in 100 ml of acetone. Stir and maintain at room temperature. The next day, the title compound precipitate is collected by means of filtration and washed with acetone and with ether.

후처리

  1. filtrationThe next day, the title compound precipitate is collected by means of filtration
  2. washwashed with acetone and with ether

출처 및 근거

ORD 기록
ord-f4339df29ca54a168736e149c389c23f
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623073

연결된 노트

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