Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 4-bromo-alpha-hydroxybenzeneacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | p-Bromomandelic acid | HCID 97930 | — |
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Methyl 4-bromo-alpha-hydroxybenzeneacetate | HCID 14571696 | 93.2% |
반응 단계
A solution of trimethylsilyldiazomethane in hexane (2 M, 1.4 mL, 2.8 mmol) was added to a solution of 4-bromo-phenyl-hydroxy-acetic acid (506 mg, 2.19 mmol) in benzene (2.1 mL)-methanol (1.0 mL) under cooling with ice, and the mixture was stirred at room temperature for five minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1) to give the title compound (500 mg, 93%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07935688B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-b20975e893d9451080f5f154d764a445 |
| 출처 메모 | uspto-grants-2011_05 |